Browsing by Author "Erdogan, Mumin Alper"

Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model

Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)

The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ...

Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy

Karahan, Gokhan; Kaya, Huseyin; Eyceyurt, Recep Selcuk; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun (Spandidos Publ Ltd, 2021)

The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ...

Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia

Erdogan, Mumin Alper; Kirazlar, Mehmet; Yigitturk, Gurkan; Erbas, Oytun (Springer/Plenum Publishers, 2021)

Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ...

Effect of Lipid Emulsion on the Improvement of Renal Damage in Colist-in-Induced Nephrotoxicity

Senkal, Naci; Atasoy, Ozum; Caparali, Emine Bilge; Erdogan, Mumin Alper; Erbas, Oytun (Bentham Science Publ, 2021)

Background: Colistin utilization has gradually increased worldwide with the rising of multidrug-resistant (MDR) gram-negative bacilli despite its nephrotoxicity. Lipid emulsion (LE) is widely used for the toxic overdose ...

The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats

Bora, Saylav; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Parlak, Ismet (HUMANA PRESS INC, 2018)

The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ...

Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions

Erdogan, Arife; Erdogan, Mumin Alper; Atasoy, Ozum; Erbas, Oytun (Springer/Plenum Publishers, 2021)

Millions of people suffer from drug-resistant epilepsy. New therapeutic approaches for removing this life-affecting disease are required. The activation of T-type calcium channels (TTCC) is one of the epileptogenesis ...

Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study

Sunnetci, Eda; Durankus, Ferit; Albayrak, Yakup; Erdogan, Mumin Alper; Atasoy, Ozum; Erbas, Oytun (Korean Coll Neuropsychopharmacology, 2021)

Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its ...

Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism

Solmaz, Volkan; Erdogan, Mumin Alper; Alnak, Alper; Meral, Ayfer; Erbas, Oytun (Churchill Livingstone, 2020)

We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female ...

Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study

Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)

The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ...

Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions

Solmaz, Volkan; Tekatas, Aslan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2020)

Previous studies have established anti-inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to have important roles in the pathophysiology ...

An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment

Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Alper, Sibel; Erbas, Oytun (Hindawi Ltd, 2021)

Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ...

Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)

Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ...

Induction of Behavioral and Histological Alterations in Rats by Chronic Consuming of Artificial Sweeteners: A Comparative Study

Erdogan, Mumin Alper; Erbas, Oytun; Khalilnezhad, Asghar; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY-BLACKWELL, 2016)

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Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy

Erdogan, Mumin Alper; Yusuf, Dimas; Erdogan, Arife; Erbas, Oytun (ELSEVIER SCIENCE BV, 2019)

Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure ...

Neurobehavioral effects of long-term maternal fructose intake in rat offspring

Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Meral, Ayfer; Taskiran, Dilek (PERGAMON-ELSEVIER SCIENCE LTD, 2018)

Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective: We aimed to investigate the influence of long-term maternal ...

Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats

Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2021)

Aim Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ...

The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat

Tekgul, Hasan; Simsek, Erdem; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2020)

Purpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims to investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin and neuropeptide Y) and ...