Plasma levels of matrix metalloproteinase-9 in children with chronic spontaneous urticaria
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CitationDilek F, Ozceker D, Ozkaya E, Tamay Z, Yazici M, Kesgin S, Kocyigit A, Guler N. Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria. Allergy Asthma Immunol Res. 2016; 8(6): 522-526. doi: 10.4168/aair.2016.8.6.522
Purpose: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. Methods: The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS).