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dc.contributor.authorİsbir, Turgay
dc.contributor.authorDemircan, Berna
dc.contributor.authorKıraç, Deniz
dc.contributor.authorDalan, Burak
dc.contributor.authorGörmüş, Uzay
dc.contributor.editorVengrova, Sonyaen_US
dc.identifier.citationIsbir T, Demircan B, Kirac D, Dalan B, Gormus U. (2011). DNA repair, cancer and cancer therapy- the current state of art. In: DNA repair and human health. Ed. Vengrova S. Rijeka, InTech Pub., pp. 279-306.en_US
dc.descriptionİstanbul Bilim Üniversitesi, Tıp Fakültesi.en_US
dc.description.abstractOver the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being.en_US
dc.description.tableofcontentsChapter 1 DNA Repair, Human Diseases and Aging by Vaidehi Krishnan, Baohua Liu and Zhongjun Zhou Chapter 2 Double Strand Break Signaling in Health and Diseases by Marie-jo Halaby and Razqallah Hakem Chapter 3 DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants by Augusto Nogueira, Raquel Catarino and Rui Medeiros Chapter 4 The Role of Error-Prone Alternative Non-Homologous End-Joining in Genomic Instability in Cancer by Li Li, Carine Robert and Feyruz V. Rassool Chapter 5 Nucleotide Excision Repair and Cancer by Joost P.M. Melis, Mirjam Luijten, Leon H.F. Mullenders and Harry van Steeg Chapter 6 Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum by Carolina Quayle, Carlos Frederico Martins Menck and Keronninn Moreno Lima-Bessa Chapter 7 DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy by Ana M. Urbano, Leonardo M. R. Ferreira, Joana F. Cerveira, Carlos F. Rodrigues and Maria C. Alpoim Chapter 8 DNA Repair, Cancer and Cancer Therapy by Mu Wang Chapter 9 DNA Repair, Cancer and Cancer Therapy - The Current State of Art by Turgay Isbir, Berna Demircan, Deniz Kirac, Burak Dalan and Uzay Gormus Chapter 10 Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment by Anna Tompa, Jenő Major and Mátyás G. Jakab Chapter 11 Hypoxia Inhibits DNA Repair to Promote Malignant Progression by L. Eric Huang, Young-Gun Yoo, Minori Koshiji and Kenneth K.W. To Chapter 12 From the Molecular Biology to the Gene Therapy of a DNA Repair Syndrome: Fanconi Anemia by Paula Río, Susana Navarro and Juan A. Bueren Chapter 13 Fanconi Anemia/Brca Pathway and Head and Neck Squamous Cell Carcinomas by Shi-Long Lu Chapter 14 DNA Repair Deficiency Associated with Hematological Neoplasms by Panagiota Economopoulou, Vassiliki Pappa, Sotirios Papageorgiou, John Dervenoulas and Theofanis Economopoulos Chapter 15 DNA Repair in Acute Myeloid Leukemia and Myelodysplastic Syndromes by Anna Szmigielska-Kaplon and Tadeusz Robak Chapter 16 Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells by Haiyan Wang, Shanbao Cai, Eva Tonsing-Carter and Karen E. Pollok Chapter 17 DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms by Susana N. Silva, Bruno Costa Gomes, José Rueff and Jorge Francisco Gaspar Chapter 18 DNA Mismatch Repair (MMR) Genes and Endometrial Cancer by Kenta Masuda, Kouji Banno, Megumi Yanokura, Iori Kisu, Arisa Ueki, Asuka Ono, Yusuke Kobayashi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu and Daisuke Aoki Chapter 19 Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer by Rachel M. Abbotts, Christina Perry and Srinivasan Madhusudan Chapter 20 Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy by Tracy M. Neher, Wei Huang, Jian-Ting Zhang and John J. Turchi Chapter 21 Pharmacogenomic Approach of Telomerase in Cancer: Importance of End Zone Variability by R. Catarino, A. Nogueira, A. Coelho and R. Medeiros Chapter 22 Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells by Christine Granotier and François D. Boussin Chapter 23 Pharmacogenetics of Cancer and DNA Repair Enzymes by Tahar van der Straaten, Leon Mullenders and Henk-Jan Guchelaar Chapter 24 Involvement of Histone PTMs in DNA Repair Processes in Relation to Age-Associated Neurodegenerative Disease by Chunmei Wang, Erxu Pi, Qinglei Zhan and Sai-ming Ngai Chapter 25 Transcriptional Functions of DNA Repair Proteins Involved in Premature Aging by Robin Assfalg and Sebastian Iben Chapter 26 DNA Damage and mRNA Levels of DNA Base Excision Repair Enzymes Following H2O2 Challenge at Different Temperatures by Kyungmi Min and Susan E. Ebeler Chapter 27 Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency Syndromes by Sarah Vose and James Mitchell Chapter 28 The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration by Kei Adachi and Hiroyuki Nakai Chapter 29 Integration of the DNA Damage Response with Innate Immune Pathways by Gordon M. Xiong and Stephan Gasser Chapter 30 Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer by Harpreet K. Dibra, Chris J. Perry and Iain D. Nicholl Chapter 31 Inhibition of DNA Polymerase λ, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives by Yoshiyuki Mizushina, Masayuki Nishida, Takeshi Azuma and Masaru Yoshidaen_US
dc.titleDNA repair, cancer and cancer therapy- the current state of arten_US
dc.description.version1. baskıen_US
dc.contributor.departmentDBÜ, Tıp Fakültesien_US

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