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dc.contributor.authorPullinger, Clive R.
dc.contributor.authorGoldfine, Ira D.
dc.contributor.authorTanyolac, Sinan
dc.contributor.authorMovsesyan, Irina
dc.contributor.authorFaynboym, Mark
dc.contributor.authorDurlach, Vincent
dc.contributor.authorKane, John P.
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T16:02:44Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T16:02:44Z
dc.date.issued2014
dc.identifier.issn1540-4196
dc.identifier.issn1557-8518
dc.identifier.urihttps://dx.doi.org/10.1089/met.2013.0086
dc.identifier.urihttp://hdl.handle.net/11446/2900
dc.descriptionWOS: 000330808200004en_US
dc.descriptionPubMed ID: 24148075en_US
dc.description.abstractBackground: High-mobility group AT-hook 1 (HMGA1) is an important regulator of the insulin receptor gene. We have previously shown in three populations of white European ancestry that the HMGA1 gene variant rs146052672 (also designated IVS5-13insC) is associated with type 2 diabetes mellitus (T2DM). The aim of this study was to measure the frequency of this variant and to determine the degree of the association with T2DM and other features of the metabolic syndrome in a replication cohort of Hispanic Americans. Methods: This was a retrospective cohort study of well-characterized Hispanic-American participants analyzed in the Genomic Resource in Atherosclerosis (GRA) (Cardiovascular Research Institute, University of California, San Francisco). A total of 1144 individuals were studied, 320 of whom had T2DM. We examined associations of the rs146052672 SNP with T2DM, plasma lipids, lipoproteins, and body mass index (BMI). Results: In this Hispanic-American cohort, the HMGA1 rs146052672 minor allele (C-insertion) frequency (MAF) was 21.4% with a carrier frequency of 37.4%, considerably higher than we previously observed among GRA white Europeans (MAF 3.1%). The prevalence of the IVS5-13insC variant was significantly higher in those with T2DM compared to controls [42.2% vs. 35.5%; odds ratio (OR) 1.44 95% confidence interval (CI) 1.09-1.90, P=0.011). The variant was also associated with BMI (positively, P=0.045) and plasma high-density lipoprotein cholesterol (HDL-C) (negatively, P=0.047). Conclusions: As we saw previously among white Europeans, a functional HMGA1 variant was associated with T2DM in individuals of Hispanic-American ethnicity and was present at a much higher frequency.en_US
dc.description.sponsorshipDiabetes Research Fund of Mount Zion Health Fund; Jewish Community Endowment Fund; Hellman Family Award; UCSF; Campini Foundation; Joseph Drown Foundationen_US
dc.description.sponsorshipThis work was supported by the Diabetes Research Fund of Mount Zion Health Fund, a supporting foundation of the Jewish Community Endowment Fund (I.D.G. and C.R.P.), a Hellman Family Award (C.R.P.), a UCSF Academic Senate Award (C.R.P.), the Campini Foundation, the Joseph Drown Foundation (M.J.M.), and by gifts from Peter Read, Donald Yellon, and the Mildred V. Strouss Charitable Trust.en_US
dc.language.isoengen_US
dc.publisherMARY ANN LIEBERT, INCen_US
dc.relation.isversionof10.1089/met.2013.0086en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEvidence That an HMGA1 Gene Variant Associates with Type 2 Diabetes, Body Mass Index, and High-Density Lipoprotein Cholesterol in a Hispanic-American Populationen_US
dc.typearticleen_US
dc.relation.journalMETABOLIC SYNDROME AND RELATED DISORDERSen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume12en_US
dc.identifier.startpage25en_US
dc.identifier.endpage30en_US
dc.contributor.authorID0000-0003-1533-8779en_US
dc.contributor.authorID0000-0001-5329-3124en_US
dc.contributor.authorID0000-0002-9536-5736en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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