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dc.contributor.authorTugcu, Aylin
dc.contributor.authorGuzel, Deniz
dc.contributor.authorYildirimturk, Ozlem
dc.contributor.authorAytekin, Saide
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T16:05:10Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T16:05:10Z
dc.date.issued2009
dc.identifier.issn0008-6312
dc.identifier.issn1421-9751
dc.identifier.urihttps://dx.doi.org/10.1159/000193146
dc.identifier.urihttp://hdl.handle.net/11446/3441
dc.descriptionWOS: 000263747400006en_US
dc.descriptionPubMed ID: 19151552en_US
dc.description.abstractObjectives: We investigated right ventricular (RV) structural and functional cardiac alterations in obstructive sleep apnea (OSA) independent of systemic hypertension and their correlation to the severity of OSA. Methods: Forty-one moderate-to-severe OSA but otherwise healthy patients and 30 body mass index-matched control subjects were included. All subjects underwent 24-hour ambulatory blood pressure monitoring, standard and tissue Doppler imaging of the RV. Results: The OSA group had increased RV wall thickness, impaired right ventricular outflow tract fractional shortening (RVOT fs), tricuspid annular plane systolic excursion (TAPSE), RV myocardial performance index (MPI) and RV myocardial acceleration during isovolumic contraction (IVA) (p < 0.001). Apnea hypopnea index (AHI) and mean pulmonary artery (PA) pressure were correlated with all these indices (p < 0.01 for all). RV free wall thickness (p < 0.001) and IVA (p = 0.006) remained significant predictors of AHI after adjusting for age, body mass index, mean PA pressure, RVOT fs, TAPSE and MPI in a multiple stepwise linear regression model. Conclusions: OSA is associated with impaired RV function despite normal systemic blood pressures. The level of RV dysfunction has a direct relationship with the severity of OSA. RV free wall thickness and IVA are independent predictors of AHI in uncomplicated OSA patients. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.language.isoengen_US
dc.publisherKARGERen_US
dc.relation.isversionof10.1159/000193146en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleep apneaen_US
dc.subjectEchocardiographyen_US
dc.subjectBlood pressureen_US
dc.subjectVentricular functionen_US
dc.titleEvaluation of Right Ventricular Systolic and Diastolic Function in Patients with Newly Diagnosed Obstructive Sleep Apnea Syndrome without Hypertensionen_US
dc.typearticleen_US
dc.relation.journalCARDIOLOGYen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue3en_US
dc.identifier.volume113en_US
dc.identifier.startpage184en_US
dc.identifier.endpage192en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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