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dc.contributor.authorSunnetci Silistre, Eda
dc.contributor.authorErbas, Oytun
dc.date.accessioned2020-12-02T18:01:21Z
dc.date.available2020-12-02T18:01:21Z
dc.date.issued2020
dc.identifier.issn2146-4618
dc.identifier.issn2146-4626
dc.identifier.urihttps://doi.org/10.1055/s-0040-1710587
dc.identifier.urihttp://hdl.handle.net/11446/3584
dc.descriptionWOS: 000583627400006en_US
dc.descriptionPubMed: 33133742en_US
dc.description.abstractAlthough the exact pathophysiology of critical illness polyneuropathy (CIP) is still unknown, there are several hypotheses, some of which are increased inflammation and oxidative stress. We used rodent sepsis model in which we induced sepsis through cecal ligation followed by cecal puncture. We then administered ascorbic acid (AA) and evaluated outcomes. the levels of malondialdehyde (MDA), tumor necrosis factor alpha (TNF-alpha), interleukins (IL)-6 in the plasma, and heat shock protein-70 (HSP-70) levels in the sciatic nerve were measured, and also electromyography analyses were performed. While plasma MDA, TNF-alpha, and IL-6 levels were decreased significantly with AA treatment, sciatic nerve levels of HSP-70 were significantly elevated in the AA group. A significant increase in compound muscle action potential (CMAP) amplitude and a significant decrease in CMAP latency were detected in the AA group. We observed healing effects of AA on a rat model of CIP and these effects seem to be related to its anti-inflammatory and antioxidant properties.en_US
dc.language.isoengen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.isversionof10.1055/s-0040-1710587en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcritical illness polyneuropathyen_US
dc.subjectsepsisen_US
dc.subjectascorbic aciden_US
dc.subjectmalondialdehydeen_US
dc.subjectcompound muscle action potentialen_US
dc.titleThe Ameliorative Effects of Ascorbic Acid on Critical Illness Polyneuropathy in Rodent Sepsis Modelen_US
dc.typearticleen_US
dc.relation.journalJournal of Pediatric Intensive Careen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue04en_US
dc.identifier.volume09en_US
dc.identifier.startpage265en_US
dc.identifier.endpage270en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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