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dc.contributor.authorTekgul, Hasan
dc.contributor.authorSimsek, Erdem
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorErbas, Oytun
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2020-12-02T18:01:46Z
dc.date.available2020-12-02T18:01:46Z
dc.date.issued2020
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.urihttps://doi.org/10.1080/00207454.2019.1667791
dc.identifier.urihttp://hdl.handle.net/11446/3718
dc.descriptionTaskiran, Dilek/0000-0002-4505-0939; Erdogan, Mumin/0000-0003-0048-444Xen_US
dc.descriptionWOS: 000488416100001en_US
dc.descriptionPubMed: 31518546en_US
dc.description.abstractPurpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims to investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin and neuropeptide Y) and neurotrophic factors (BDNF and NGF) in pentylenetetrazol (PTZ)-kindled seizures in the rat. Methods: Forty-eight adult male Sprague?Dawley rats were included in the study. the animals were divided into 8 groups of six rats. Group 1 was defined as na?ve control, and received no medication. Group 2 (PTZ?+?saline) was treated with sub-convulsive doses of PTZ (35?mg/kg) and saline i.p. for 14?days. For anticonvulsant treatments, Groups 3?8 were treated with 200?mg/kg levetiracetam (PTZ?+?LEV), 1?mg/kg midazolam (PTZ?+?MDZ), 80?mg/kg phenytoin (PTZ?+?PHT), 80?mg/kg topiramate (PTZ?+?TPR), 40?mg/kg lamotrigine (PTZ?+?LMT) and 50?mg/kg sodium valproate (PTZ?+?SV), respectively. All anticonvulsant drugs were injected 30 min prior to PTZ injection throughout 14?days. Following treatment period, behavioral, biochemical and immunohistochemical studies were performed. Results: PTZ?+?saline group revealed significantly decreased galanin, NPY, BDNF and NGF levels compared to control. PTZ?+?MDZ group had significantly increased galanin, BDNF and NGF levels compared to saline group. Also, PTZ?+?LEV group showed increased BDNF levels. PTZ?+?saline group revealed significantly lower neuron count and higher GFAP (+) cells in hippocampal CA1?CA3 regions. All anticonvulsants significantly reduced hippocampal astrogliosis whereas only midazolam, levetiracetam, sodium valproate and lamotrigine prevented neuronal loss. Conclusion: Our results suggested that anticonvulsant drugs may reduce the severity of seizures, and exert neuroprotective effects by altering the expression of neuropeptides and neurotrophins in the epileptogenic hippocampus.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.isversionof10.1080/00207454.2019.1667791en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectgalaninen_US
dc.subjectneuropeptide Yen_US
dc.subjectBDNFen_US
dc.subjectNGFen_US
dc.subjectanticonvulsant drugsen_US
dc.titleThe potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the raten_US
dc.typearticleen_US
dc.relation.journalInternational Journal of Neuroscienceen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue2en_US
dc.identifier.volume130en_US
dc.identifier.startpage193en_US
dc.identifier.endpage203en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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